Slide 2 of 5 of Coagulación sanguínea. VÍA EXTRÍNSECA; 2. Vía Intrínseca; 3. Conversión de la Vías y cascada de la coagulación. Enzimas que actuan en la coagulación.c. Asignatura: .. Al final, las vías intrínse cas y extrínsecas confluyen en una secuencia de etapas en común. hasta. Los factores de la coagulación de la vía extrínseca se activan al producirse el La coagulación también puede activarse por la vía intrínseca al entrar en.

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Studies on coagullacion arabinan sulfates form the green alga, Codium latum. This last molecule is a sulfated glicosaminoglycan used in oral therapy for anticoagulant disorders. Introduction to Applied Phycology. Pharmacological activities of marine algae. Anticoagulant and antithrombin activities of oversulfated fucans.

Similar results of slightly anticoagulant potency were observed but in thrombin time test for C. In the laboratory the material coagulacionn thawed at room temperature and a fraction of this was preserved in glycerinated formaldehyde for species determination and Voucher organisms, this specimens were kept in our laboratory as internal reference material.

Purification and characterization of a fibrinolytic enzyme and identification of fibrinogen clotting enzyme in a marine green alga Codium divaricatum.

Naito K, Fujikawa K Apr Journal xascada Thrombosis and Haemostasis: Propiedades anticoagulantes de extractos de algas marinas mexicanas: Chemical structure of antithrombin-active Rhamnan sulfate from Monostroma nitidum. Standardized plasma coagulation tests thrombin and prothrombin time were used. Results Results for algal extracts in both anticoagulant tests are in table 1.

Thrombosis is a health problem that affects many people in the world.

En humanos, el factor XI se encuentra codificado por el gen F Seligsohn U Jul We considered an algal extract with anticoagulant activity similar to heparin when this impede the clot formation during 10 minutes or more. Anadyomene stellataCaulerpa cupressoides ChlorophytaLobophora variegata Phaeophyta and Liagora farinosa Rhodophyta.


Biological activity of extracts from some Mediterranean macrophytes. Structure and anticoagulant activity of a fucosylated chondroitin sulfate from echinoderm.

Detección de sustancias anticoagulantes en algunas macroalgas marinas

Forty nine seaweed species collected off shore of several localities of Gulf of Mexico and Mexican Caribbean sea were screened in order to detect anticoagulant activity in both intrinsic and extrinsic pathways of clot formation. Niveles elevados de factor XI han sido implicados en casos de trombosis coagulaciln, aunque es incierto que es lo que determina estos niveles, y cuan severo puede ser el estado procoagulante.

The sites of collection of Veracruz state were: A delay in clot formation less than two minutes was observed in prothrombin time test for this species from Chlorophyta: Nucleic Acids Research 19 Further data on the structure of brown seaweed fucans: This is the first report of anticoagulant activity in Anadyomene stellataLobophora variegata and Liagora farinosa. Se concluye que estas especies pueden ser consideradas como una fuente alternativa de nuevos anticoagulantes.

Materials and methods The samples for this study were manually collected from the seven localities described above, from the Gulf of Mexico and Mexican Caribbean sea during May to October figure 1were classified by genus and transported frozen to the laboratory using solid CO 2.

Agardh, ChlorophytaLobophora variegata Lamoroux Womersley Phaeophyta and Liagora farinosa Lamouroux Rhodophyta were as potent as heparin impeding the clot formation in both extrinsdca and prothrombin time tests.

The research effort has been focused on one genus, forgotten the basic detection of different algae as a potential source of alternative anticoagulant molecules. Cryptogamie Algolologie 16 3: Journal of Phycology We considered that extracts who acted on both path-ways of clot formation, affect the cascade of coagulation in the point of convergence, that is in transformation of fibrinogen to fibrin.


The results showed other algae with slightly inhibition of clot formation activity, it is not common to consider this species for further investigation, nevertheless the retardation of formation of clot by Penicillus capitatusa coagulacoon evolutionary related to Halimeda genus Vroom et al.

We considered that algal extracts have substances capable of inhibit clot formation in the last steps of the coagulation cascade. Structure and anticoagulant activity of sulfated galactans. Blood coagulation and haemostasis. On the quantitative estimation of prothrombin. Agardh Rhodophyta retarded the coagulation process of human plasma in both anticoagulant tests for less than two minutes period and more than one minute.

Intrniseca of Biological Chemistry Antihaemostatic activities of British marine algae.

Journal of Applied Phycology Cascxda and characterization of two fibrinolytic enzymes from the marine green alga, Codium intricatum. Se reporta por primera vez la actividad anticoagulante de Anadyomene stellataLobophora variegata y Liagora farinosa.

Factor de coagulación XI

The samples for this study were manually collected from the seven localities described above, from the Gulf of Mexico and Coaguacion Caribbean sea during May to October figure 1were classified by genus and transported frozen to the laboratory using solid CO 2.

Anadyomene stellataCaulerpa cupressoides ChlorophytaLobophora variegata Phaeophyta y Liagora farinosa Rhodophyta. We can concluded that these species can be considered as potentially alternative source of anticoagulant molecules.