dales vasomotor reversal and rereversal by using alpha and beta blockers. In neuroscience, Dale’s principle (or Dale’s law) is a rule attributed to the English neuroscientist Henry Hallett Dale. The principle basically states that a neuron. A very simple explanation for vasomotor reversal of Dale. Adrenaline/ Epinephrine: Blood pressure changes has biphasic response; Initially.

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I wish I was as enthusiastic as you are, when it comes to studying. Oh well, I’m glad you could use my enthusiasm! Hope you rock studies in your own unique way: Thanks for the explanation Brother This is a biphasic response of adrenaline not Reversal of dale.

Dale’s principle – Wikipedia

S u can add a little bit of extra info here, i. B blockers are also used to treat hypertension. We said that after administration of a alpha blocker, we saw a fall in blood pressure. Then, let’s say, we administer propanolol.

Propranolol blocks beta receptors, so it will gradually cause rise in BP. Why are beta blockers used to treat hypertension? There is a long explanation for that. You’re probably in the beginning of your term and textbook right now. It used to bother me as well You’re not the only one!

Dale’s principle

I’ll explain in short but you’ll get this gradually once you understand the cardiovascular system, you’ll have to be patient in understanding things for now. Beta blockers will cause a rise in total peripheral resistance but that is not why it is used in hypertension.


There are other “mechanisms” that when seen in the bigger picture are beneficial to patients who have hypertension. They block the renin angiotensin aldsterone system The system gasomotor retains salt and water and causes hypertension! Beta blockers also reduce cardiac work Life saving for the ischemic heart who has to do more work with less blood! Like I said, you’ll get this eventually.

Again, thanks for explaining it to me: The drug names confuse me soo much, glipizide, pioglitazone, nateglinide, pramlintide. And also, could you please share about cestodes, trematodes and nematodes? For getting the concepts right, Katzung is supremo.

It’ll take time to get a hang of the names. If mnemonics work for you, you should try making em! Try to put mechanism in the mnemonic reverxal make it simpler That’s what I do! I drew, revised and revised for remembering life cycles. Memorized and forgot xD.

Medicowesome: Vasomotor reversal of Dale

Here are some recent examples of how I make my pharmacology mnemonics – http: Hey does d action of adrenaline on beta 1 receptors in d heart come under dale’s vasomotor reversal? This is express yourself space. Where you type create something beautiful!

Tell us something you know better. You are a brilliant mind. Comment all you like here!


Secret Projects Immunology Comics. Saturday, November 26, Vasomotor reversal of Dale.

Vasomotor reversal of Dale So what happens if you block only the alpha receptors? A fall in blood pressure due to beta mediated vasodilation!

This is known as vasomotor reversal of Dale: D To be specific, the receptors involved are Alpha 1 and Beta 2 receptors. Have an amazing weekend! Mnemonic on 28 Nov, Noradrenaline and adrenaline mnemonic.

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